Person

Prof  Mahmoud Soliman

Telephone

Fax

 +27 (0) 312608048

+27 (0) 312607872

Email

soliman@ukzn.ac.za

mess20@bath.ac.uk

Campus

 Westville

Research Interests

Molecular Modeling & Drug Design

Designation

Dean and Head of School

Prof. Mahmoud Soliman (B. Pharm., M. Pharm., PhD), Dean and Head of School at the School of Health Sciences, UKZN, Westville Campus, joined the school in 2011.  Soliman has completed his postgraduate studies (MPhil/PhD – Oct. 2009) at the University of Bath – United Kingdom in field of Molecular Modeling, computational chemistry and drug design, under supervision of Prof. Ian Williams.

Prof. Soliman is the “Editor-in-Chief” of the journal of Organic and Bimolecular Simulations (JOBS), published by Science Publisher, USA, and Editor of Journal of Pharmaceutical Chemistry and Journal of Drug Design and Research. Soliman is also academic visitor at the University of Bath, UK, collaborating with Prof. Ian Williams’ lab.

Soliman is the head of Molecular Modeling and Drug Design lab (http://soliman.ukzn.ac.za). Soliman’s research mainly focuses on studying biomolecular systems and drug-target interactions at molecular level –  see the full research scope here and publications here.

Researchgate Profile

Maharaj Y, Soliman ME. Chem Biol Drug Des. 2013 Aug;82(2):205-15. doi: 10.1111/cbdd.12152.

PMID: 23614896

Linear and cyclic glycopeptide as HIV protease inhibitors.

Pawar SA, Jabgunde AM, Maguire GE, Kruger HG, Sayed Y, Soliman ME, Dhavale DD, Govender T. Eur J Med Chem. 2013 Feb;60:144-54. doi: 10.1016/j.ejmech.2012.11.018. Epub 2012 Nov 29.

PMID: 23291117

Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes.

Soliman ML, Combs CK, Rosenberger TA. J Neuroimmune Pharmacol. 2013 Mar;8(1):287-300. doi: 10.1007/s11481-012-9426-4. Epub 2012 Dec 12.

PMID: 23233245

Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance.

Naicker P, Achilonu I, Fanucchi S, Fernandes M, Ibrahim MA, Dirr HW, Soliman ME, Sayed Y. J Biomol Struct Dyn. 2013 Dec;31(12):1370-80. doi: 10.1080/07391102.2012.736774. Epub 2012 Nov 12.

PMID: 23140382

Comparison of the molecular dynamics and calculated binding free energies for nine FDA-approved HIV-1 PR drugs against subtype B and C-SA HIV PR.

Ahmed SM, Kruger HG, Govender T, Maguire GE, Sayed Y, Ibrahim MA, Naicker P, Soliman ME. Chem Biol Drug Des. 2013 Feb;81(2):208-18. doi: 10.1111/cbdd.12063. Epub 2012 Nov 19.

PMID: 23017010

 Acetate reduces microglia inflammatory signaling in vitro.

Soliman ML, Puig KL, Combs CK, Rosenberger TA.

J Neurochem. 2012 Nov;123(4):555-67. doi: 10.1111/j.1471-4159.2012.07955.x. Epub 2012 Sep 28.

PMID: 22924711

Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors.

Makatini MM, Petzold K, Arvidsson PI, Honarparvar B, Govender T, Maguire GE, Parboosing R, Sayed Y, Soliman ME, Kruger HG. Eur J Med Chem. 2012 Nov;57:459-67. doi: 10.1016/j.ejmech.2012.06.019. Epub 2012 Jul 16.

PMID: 22867528

Pentacycloundecane-diol-based HIV-1 protease inhibitors: biological screening, 2D NMR, and molecular simulation studies.

Honarparvar B, Makatini MM, Pawar SA, Petzold K, Soliman ME, Arvidsson PI, Sayed Y, Govender T, Maguire GE, Kruger HG. ChemMedChem. 2012 Jun;7(6):1009-19. doi: 10.1002/cmdc.201100512. Epub 2012 Apr 27.

PMID: 22544389

Synthesis and molecular modelling studies of novel carbapeptide analogs for inhibition of HIV-1 protease.

Pawar SA, Jabgunde AM, Govender P, Maguire GE, Kruger HG, Parboosing R, Soliman ME, Sayed Y, Dhavale DD, Govender T. Eur J Med Chem. 2012 Jul;53:13-21. doi: 10.1016/j.ejmech.2012.03.027. Epub 2012 Apr 4.

PMID: 22542107

Synthesis, 2D-NMR and molecular modelling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors.

Makatini MM, Petzold K, Alves CN, Arvidsson PI, Honarparvar B, Govender P, Govender T, Kruger HG, Sayed Y, JerônimoLameira, Maguire GE, Soliman ME.

J Enzyme Inhib Med Chem. 2013 Feb;28(1):78-88. doi: 10.3109/14756366.2011.633907. Epub 2012 Feb 17.

PMID: 22339087

Multicomponent synthetic polymers with viral-mimetic chemistry for nucleic acid delivery.

Soliman M, Nasanit R, Abulateefeh SR, Allen S, Davies MC, Briggs SS, Seymour LW, Preece JA, Grabowska AM, Watson SA, Alexander C.

Mol Pharm. 2012 Jan 1;9(1):1-13. doi: 10.1021/mp200108q. Epub 2011 Dec 19.

PMID: 22142438

Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors.

Karpoormath R, Sayed Y, Govender P, Govender T, Kruger HG, Soliman ME, Maguire GE. Bioorg Chem. 2012 Feb;40(1):19-29. doi: 10.1016/j.bioorg.2011.08.002. Epub 2011 Aug 16.

PMID: 21982718

Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: a hybrid 2D NMR and docking/QM/MM/MD approach.

Makatini MM, Petzold K, Sriharsha SN, Ndlovu N, Soliman ME, Honarparvar B, Parboosing R, Naidoo A, Arvidsson PI, Sayed Y, Govender P, Maguire GE, Kruger HG, Govender T. Eur J Med Chem. 2011 Sep;46(9):3976-85. doi: 10.1016/j.ejmech.2011.05.071. Epub 2011 Jun 7.

PMID: 21741133

Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease.

Makatini MM, Petzold K, Sriharsha SN, Soliman ME, Honarparvar B, Arvidsson PI, Sayed Y, Govender P, Maguire GE, Kruger HG, Govender T. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2274-7. doi: 10.1016/j.bmcl.2011.02.105. Epub 2011 Mar 1.

PMID: 21429747

Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression.

Soliman ML, Rosenberger TA. Mol Cell Biochem. 2011 Jun;352(1-2):173-80. doi: 10.1007/s11010-011-0751-3. Epub 2011 Feb 26.

PMID: 21359531

Modular construction of multifunctional bioresponsive cell-targeted nanoparticles for gene delivery.

Saeed AO, Magnusson JP, Moradi E, Soliman M, Wang W, Stolnik S, Thurecht KJ, Howdle SM, Alexander C. Bioconjug Chem. 2011 Feb 16;22(2):156-68. doi: 10.1021/bc100149g. Epub 2011 Jan 11.

PMID: 21222431