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PhD Graduates in 2015

PhD Graduates in 2015

Ajayi, Nasirudeen Oladipupo

Ajayi, Nasirudeen Oladipupo, MBChB(UIbadan), MMedSc.......................................................... Anatomy

Dissertation: Anatomic and functional significance of the coronary collateral pathways in coronary arterial obstruction

Supervisor: Professor KS Satyapal

Cardiovascular disease is an increasing cause of death and disability. Coronary collateral arteries are alternative conduits for blood flow in coronary obstruction. The current classification of these collateral arteries depends on several methods resulting in difficulties in scientific communication as well as in functional assessment. The study proposed a uniform algorithm for coronary collateral classification and found thatwell-developed collaterals preserve left ventricular function. The presence of well-developed collaterals may influence decision making in clinical management.


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Apalata, Teke

Apalata, Teke, MBBS(UKinshasa), MMed................................................................ Medical Microbiology

Dissertation: Immunopathogenesis of vulvo vaginal candidiasis in HIV infected women

Supervisor: Professor P Moodley

NDABAONLINE Article

In HIV infected women, vulvo-vaginal candidiasis (VVC) is recurrent and less responsive to conventional anti-fungal therapy. The pathogenesis of recurrent VVC is not well understood. In this study, the candidate found that Th17 and regulatory T cells rather than Th1/Th2 paradigm are key players in the defense and development of effector responses in the vagina of VVC patients co-infected with HIV. He further showed a decrease in TLR-2 mediated responses by Candida in HIV infected women. 


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Baxter, Cheryl

Baxter, Cheryl, BSc, BScHons, MSc....................................................................................... Public Health

Dissertation: Impact of Intermittent Tenofovir 1% gel on Hepatitis B Virus (HBV) infection

Supervisor: Professor SS Abdool Karim


NDABAONLINE Article

Tenofovir, the most widely used drug to treat AIDS, can lead to rebound hepatic flares, a severe form of liver disease, in people with hepatitis B. A randomised controlled trial showed that intermittent application of tenofovir 1% gel for HIV prevention did not lead to alterations in hepatitis B acquisition rates, hepatitis B viral load, hepatic flares or tenofovir resistance genetic mutations. The study showed that tenofovir gel can be safely applied by women with hepatitis B virus infection.

 


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Bhorat, Ismail Essop

Bhorat, Ismail Essop, MBChB(UN), FCOG (SA)(CollMedSA)....................... Obstetrics and Gynaecology

Dissertation: Fetal cardiac haemodynamics in normal and complicated pregnancies

Supervisor: Professor JS Bagratee

NDABAONLINE Article


Dr Bhorat has used fetal echocardiography with Doppler to measure the Myocardial Performance Index (MPI). This may be used as a predictor of fetal cardiac function.He has established gestational age-­‐adjusted normograms for the MPI in pregnancy. His study has demonstrated the decreasing trend of the MPI and its component reference intervals in terms of established cardiac physiological principles. The MPI has shown to be of high value in showing impairment of fetal cardiac function in poorly controlled gestational diabetes, in severe  preeclampsia and infetuses with intrauterine growth impairment. These findings will assist clinicians in their care of pregnant women.

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Boadi-Kusi, Samuel Bert

Boadi-Kusi, Samuel Bert, BScHons(UCapeCoast), BOptom(UCapeCoast), MPhil(UCapeCoast) Optometry

Dissertation: Ocular health of cocoa farmers in Ghana: An assessment and intervention study

Supervisors: Dr R Hansraj and Mr KP Mashige


NDABAONLINE Article


The candidate assessed the visual status of cocoa farmers using standard clinical and optometric procedures to evaluate the work-relatedness of conditions identified among these workers. An assessment of the knowledge, perceptions and beliefs of these workers on ocular health and safety practices were critically examined. Based on the assessment, a training intervention programme was developed and tested among the farmers. The study contributes to a holistic understanding of the work-relatedness of the ocular conditions among cocoa farmers. Furthermore it demonstrates the possibility of positively impacting on the lives of the cocoa workers through a training programme and policy initiatives.

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Chuturgoon, Anil Amichund

Chuturgoon, Anil Amichund, BSc, BScHons, MSc................................................... Medical Biochemistry

Dissertation: An investigation into the biochemical, molecular and epigenetic effects of fumonisin B1 in liver (HepG2) cells

Supervisors: Professor B Singh and Dr D Moodley


The common carcinogenic mycotoxin Fumonisin B1 (FB1) is present in many cereal grains such as maize.  Its mechanism of carcinogenesis is unknown.  This study showed FB1 possessed epigenetic properties that influenced programmed cell death.  It was shown that FB1 induced global DNA hypomethylation and altered microRNA expression in hepatic cells.  A consequence of these epigenetic changes resulted in increased expression of the inhibitor of apoptosis family of proteins that prevented cell death.  This work resulted in publications in high impact factor journals.


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Clarke, Damian Luiz

Clarke, Damian Luiz, MBChB(Wits), MMedSc, PGDip(BusMgt), MBA......................................... Surgery

Dissertation: Developing a multi faceted approach to uplifting and improving trauma care in the periphery

Supervisors: Dr CM Aldous and Professor SR Thomson


The candidate developed a theoretical grid structure designed to facilitate management thinking about quality improvement programs in healthcare.  A situational analysis of trauma care in the Harry Gwala District and Edendale Hospital was undertaken using the grid. Findings showed a discrepancy between the burden of disease and the capacity to deal with it and revealed care of an uneven quality.  As a result, a multifaceted quality improvement program was instituted and its impact was assessed. 


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Dlamini, Colile Pertunia

Dlamini, Colile Pertunia, BN(UNISWA), MN................................................................................... Nursing

Dissertation: Developing a clinical learning model for the integration of theory and practice in nursing education in Swaziland

Supervisor: Professor NG Mtshali


NDABAONLINE Article


This inquiry emanated from the public and stakeholders’ outcry about the under preparedness of graduates for practice and how the quality of care has fallen below standard in Swaziland. A four cycled action research was adopted and a grounded theory approach was used to generate a clinical education model for the integration of theory and practice in nursing education in Swaziland. Clinical education was conceptualised as workplace learning, authentic and transformative learning experience, and the locus for theory and practice integration. Academic-service partnership and facilitation of clinical learning were connected by three action-concepts; collaboration, communication and commitment. The outcomes of the model are theory and practice integration, competent graduates and compassionate change agents motivated to transform the profession.  


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Dlova, Ncoza

Dlova, Ncoza, MBChB(UN), FC DERM(SA)(CollMedSA)..................................................... Dermatology

Dissertation: Ethnic skin and hair disorders in KwaZulu Natal: A study of the spectrum of ethnic skin and hair disorder, and the composition and use of skin-lightening preparations, traditional cosmetics and sunscreen

Supervisor: Professor RJ Hift


NDABAONLINE Article

Ethnodermatology is a rapidly growing subspecialty within dermatology. Conventional research and training in dermatology has rarely focused on ‘skin of colour’; a deficiency which ethnodermatology seeks to address.  Dr Dlova’s work includes a range of innovative studies of skin disorders in the African and Indian populations of KwaZulu-Natal, and serves as a major step forward in understanding these conditions and in planning a rational therapeutic and social response to improve the lives of those afflicted. 

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Gaede, Berhard

Gaede, Bernhard MBBCh, M.Med. (Fam Med)............................................................Family Medicine

Dissertation: Civil servant and professional – understanding the challenges of being a public service doctor in a plural health care setting in rural South Africa

Supervisor: Tessa Marcus (University of Pretoria)

 

Through an insider-ethnography the study used the lens of Lipsky’s street-level bureaucracy to explore the how the roles of professional and civil servant converge and how public sector doctors use discretion individually and collectively within their daily work. Despite a stressed public sector, the voluntarily alignment with policies to improve services makes this discretionary practice vital for the service to function. While bureaucratic and professional standards create detachment, caring engagement is contingent on the space that discretion provides. These findings have considerable implications for how the work of public sector doctors is conceptualized, planned and managed.  


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Gengiah, Tanuja Narayansamy

Gengiah, Tanuja Narayansamy, BPharm, MClinPharm.............. Therapeutics and Medicine Management

Dissertation: Integrating human immunodeficiency virus and tuberculosis drug treatment

Supervisor: Professor JH Botha


NDABAONLINE Article


HIV and TB co-infection is associated with high mortality. Integration of drug treatment for the two diseases is essential to improve survival. However, success may be compromised by drug interactions. This candidate demonstrated that rifampicin-based TB treatment unexpectedly increased concentrations of the first-line HIV drug efavirenz in the blood. This was the opposite of what was expected from previous studies in other populations. Genetic differences that influence the functioning of important drug metabolizing enzymes were found, in part, to explain these findings. The concentration of rifampicin, a critical anti-TB drug, was found to be far below the recommended target range. The candidate made two recommendations; firstly a dosage reduction of efavirenz in African HIV/TB co-infected patients to minimize possible side effects and improve life-long treatment sustainability. Secondly the rifampicin dose should be increased to limit TB treatment failures and the development of drug resistant TB.    

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Geyer, Nelouise-Marie

Geyer, Nelouise-Marie, BCur(UPret), MCur(UPret)....................................................................... Nursing

Dissertation: The influence of intrapersonal characteristics of individual nurses on their work performance: A predictive correlational study in a selected province in South Africa

Supervisors: Professor LR Uys, Dr SK Coetzee and Dr JR Naidoo


Using Structural Equation Modelling  the study of quality of nursing care in South Africa found that while professional values of nurses positively influence their work performance; their caring behaviours influence work performance through a negative correlation (meaning when patients perceive nurses caring behaviour to be high; nurses rate their work performance as low). Furthermore, professional values was identified as a significant predictor towards work performance which was two to three times a better predictor of all dimensions of nurses work performance than any other predictor added to the equation. 

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Govender, Vineshree

Govender, Vineshree, MBChB(UKZN), FCOG(SA)(CollMedSA), MMed...... Obstetrics and Gynaecology

Dissertation: The role of Adiponectin, Leptin, TNF-a and Resistin in HIV associated pre-eclampsia

Supervisors: Professor T Naicker and Professor J Moodley

NDABAONLINE Article

In light of the ubiquitous HIV infection, high pre-eclampsia and obesity prevalence in South Africa, this novel study explored the relationship amongst the three conditions. A statistically significant difference in the levels of adiponectin/leptin/resistin and TNF-α in HIV positive non-pregnant versus term pregnant population was established. More importantly, the study established an adipokine baseline for future reference with regards to South African pregnant and non-pregnant women.  


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Gumede, Emelda Zandile

Gumede, Emelda Zandile, BCur(UNIZUL), MCur(UNIZUL)........................................................ Nursing

Dissertation: An analysis of the health behaviour of children from child headed households in a selected health district in KwaZulu-Natal: An ethnographic study

Supervisor: Professor BR Bhengu


The study explored the health behavior with emphasis on the health seeking behavior and issues of access to health services for children coming from child headed households in a selected district in KwaZulu-Natal using ethnography. The lengthy and tedious process of awarding the child headed status, the ambiguity of the legislation, shortage of volunteers, unaffordable transport and the attitude of the health care professionals impacted negatively on these children. An intervention model was developed.


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Hadebe, Silindile Innocentia

Hadebe, Silindile Innocentia, BSc, BMedScHons....................................................................... Physiology

Dissertation: Transdermal delivery of insulin and Syzygium aromaticum-derived oleanolic acid by dermal patches in streptozotocin-induced diabetic rats: Effects on some selected metabolic parameters

Supervisor: Professor CT Musabayane


This study investigated whether transdermal application of pectin insulin containing dermal patches of different insulin concentrations sustain controlled release of insulin into the bloodstream of streptozotocin -induced diabetic rats with concomitant alleviation of diabetic symptoms in target tissues , most importantly, muscle and liver. The data suggest that insulin containing dermal patches deliver physiologically relevant amounts of pharmacologically active insulin which reduces blood glucose of diabetic rats and increases liver and muscle glycogen levels. 



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Khan, Sajidah

Khan, Sajidah, MBChB(UN)...................................................................................................... Cardiology

Dissertation: Telomere dynamics in Atherosclerosis

Supervisor: Professor DP Naidoo


Telomere length is a marker of biological ageing and may predict the susceptibility to, and onset of, coronary artery disease (CAD). In this study Dr Khan sought investigate the relationship telomere length and premature coronary heart disease in a high-prevalence population.

 

Mean TL was determined from leucocyte DNA through a modified qPCR assay. She examined 100 Indian males and 87 Black males with a mean age of 37 years participated. TL was significantly longer in the Black cohort. Significant differences in family history of premature CAD (32% [Indians] vs 0% [Blacks]), measures of abdominal obesity, non HDL-cholesterol and prevalence of type diabetes existed between the two groups. Race and pre-diabetes were independently associated with mean telomere length.

CONCLUSION:  Telomere length was significantly longer in Black Africans compared to Indians in this cohort of healthy young adults, perhaps reflecting a genetic susceptibility amongst Indians, and could partly explain the considerable difference in the prevalence of CAD between these population groups.

Shorter telomere length in control Indian subjects suggests that this population is  inherently at high risk of coronary heart disease.


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Jack, Caron Lee

Jack, Caron Lee, BMedScHons, LLM(MedLaw).......................................................................... Telehealth

Dissertation: Telehealth / E-Health / mHealth :  Transforming the client / physician relationships : The legal and ethical issues

Supervisor: Professor M Mars


NDABAONLINE Article


Ms Jack investigated South African health law and ethical guidelines in the field of eHealth. This included; use of informed consent and information and communication technologies and data storage in general medical and nursing practice; cell phone use by patients in rural areas and confidentiality; and the validity of informed consent for telemedicine obtained in the absence of technical terms in an indigenous language. H has outlined essential issues for regulators to address.  

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Khathi, Andile

Khathi, Andile, BMedSc, BMedScHons...................................................................................... Physiology

Dissertation: Syzygium aromaticum-derived triterpenes modulate intestinal glucose handling of streptozotocin-induced diabetic rats

Supervisor: Professor CT Musabayane


NDABAONLINE Article

Hypoglycaemic effects of plant-derived triterpenes are in part mediated via inhibition of glucose transport in the small intestine. This study evaluated the effects of Syzygium spp-derived acid (OA) and maslinic acid (MA) on key carbohydrate hydrolyzing enzymes in STZ-induced diabetic rats and consequences on postprandial hyperglycaemia. The results show that OA and MA suppress postprandial hyperglycaemia mediated in part via inhibition of carbohydrate hydrolysis and reduction of glucose transporters in the gastrointestinal tract.


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Kong, Victor

Kong, Victor, MBChB(UOtago)...................................................................................................... Surgery

Dissertation: The spectrum, outcome and cost of acute appendicitis at Edendale Hospital and its related catchment area

Supervisors: Dr CM Aldous and Dr DL Clarke


The student has shown that in the developing world the spectrum of acute appendicitis is sinister and associated with major adverse outcomes, compared to the developed world where it is mostly uncomplicated. Rural patients fare worst due to late presentation which often leads to advanced pathology and re-operation. The student developed a simple clinical prediction score to predict the need for re-operation in these patients, thus assisting with planned management of complicated appendicitis.


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Laing, Grant Llewellyn

Laing, Grant Llewellyn, MBChB(UCT)........................................................................................... Surgery

Dissertation: The construction, implementation and evaluation of surgical electronic medical record (EMR) systems within the Pietermartizburg Metropolitan Complex.  A means of implementing clinical governance to audit and improve the quality of local services.

Supervisors: Dr CM Aldous and Dr DL Clarke


NDABAONLINE Article


This study documents the development of a clinical record keeping system from a paper-based to an electronic system to facilitate clinical auditing in the Surgery Departments within the Pietermaritzburg Metropolitan Hospital Complex. Using the electronic system, data is trawled weekly for incidence and categorization of surgical adverse events. This endeavor provides the necessary foundation to identify common adverse events and inform future Quality Improvement Projects (QIP) aimed at reducing morbidity and improving quality of care.

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Loveday, Marian Patricia

Loveday, Marian Patricia, BSc(UCT), MPhil(UCT)............................................................... Public Health

Dissertation: Decentralised treatment of multi-drug resistant tuberculosis (MDR-TB) in Kwazulu-Natal: Evaluation of a pilot project

Supervisors: Dr AS Voce and Dr N Padayatchi


NDABAONLINE Article


KwaZulu-Natal is a global hotspot for the drug-resistant TB and HIV epidemics.  In a prospective cohort study of over 1500 patients, models of care for patients with drug-resistant TB were compared.  Treatment closer to patients homes in 4 decentralised sites attached to district hospitals, was more effective than care in a centralised specialised hospital, but varied across the decentralised sites.  This study also showed an association between health system performance and treatment efficacy.

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Madlala, Hlengiwe Pretty

Madlala, Hlengiwe Pretty, BSc, BMedScHons, MMedSc........................................................... Physiology

Dissertation: Mechanisms of cardiovascular effects of oleanolic acid and related synthetic oleanane derivatives: An experimental study

Supervisors: Professor CT Musabayane and Professor FR Van Heerden


NDABAONLINE Article


Reports indicate that plant-derived oleanolic acid (OA) possesses hypotensive effects in normotensive animals. To establish possible mechanism(s), the candidate investigated the effects of OA administration on blood pressure, kidney function, oxidative status of cardiac, hepatic and renal tissues in experimental models of hypertension emphasizing the roles of diet and genetic factors. The results suggest that the hypotensive effects of OA and related derivatives were mediated in part, via increased urinary sodium excretion and improved oxidative status. 

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Magula, Nombulelo Princess

Magula, Nombulelo Princess, BSc(UCT), FCP (SA)(CollMedSA)................................................. Medicine

Dissertation: Metabolic Complications of ART in a South African Black Population

Supervisor: Professor UG Lalloo


Lipodystrophy and metabolic complications in HIV-1 infected adult African subjects prior to and during 24 months of antiretroviral therapy (ART) were monitored and comparison of the study group was made withHIV- infected individuals not eligible for ART and HIV negative controls. 

Before treatment, there was no fat redistribution and absent to low prevalence of dysglycaemia. On follow-up, ART use was not associated with lipoatrophy but with increased incidence of dysglycaemia. These unique findings will no doubt contribute to currently unavailable information. 

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Maistry, Tanya

Maistry, Tanya, BMedSc, BMedScHons, MMedSc..................................................................... Cardiology

Dissertation: Genetic contribution to the risk for metabolic syndrome: an investigation of candidate gene polymorphisms related to lipid and carbohydrate metabolism in the South African population

Supervisor: Professor DP Naidoo


The candidate analysed 1000 blood samples from the Phoenix Lifestyle project , a survey undertaken in the community of Phoenix, in which coronary heart disease is a common problem. She analysed five genetic polymorphisms related to lipid and carbohydrate metabolism and examined the relationship of the gene polymorphisms to the presence of metabolic syndrome

 

Her results showed that there was a high prevalence of cardiovascular risk factors, with risk factor clustering across the age groups. This translated into a 50% prevalence  of metabolic syndrome using the recent harmonised criteria. Subjects with metabolic syndrome had low levels of physical activity.


Genetic analysis showed no significant association between  the gene polymorhisms and metabolic syndrome.  Males with adiponectin TG genotype and human paraoxonase 1 AA genotypes were inclined to have reduced HDL-C and higher systolic BP. IR males (HOMA IR values >2.6) were more likley to have the lipoprotein lipase GG genotype.


Conclusion: The pathogenesis of metabolic syndrome in this group lay not in polymorphisms studied , but correlated strongly with the component risk factors in the metabolic syndrome. This indicates that that risk factor clustering accounts for the high cardiovascular risk in this community, findings that are eminently amenable to intervention and risk reduction. The genetic risk for MS lies in its individual risk factor components rather than MS as an entity


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Manasa, Justen

Manasa, Justen, BSc(BioMedSc)(UZim), MMedSc(UZim)............................................................. Virology

Dissertation: Human immunodeficiency virus type 1 subtype C drug resistance analyses and bioinformatics resource development

Supervisor: Professor TPNA De Oliveira


NDABAONLINE Article


The candidate developed a free open-source bioinformatics database and a low cost open-access HIV drug resistance monitoring system for resource-limited settings. He subsequently applied these to monitor drug resistance in patients failing therapy in the Hlabisa sub-district and the extent to which drug resistance was transmitted to newly infected patients. He showed high-levels of drug resistance in patients failing therapy, low-levels of drug resistance transmission and highlighted the need for continuous surveillance of drug resistance.

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Mkhwanazi, Blessing Nkazimulo

Mkhwanazi, Blessing Nkazimulo, BSc, BScHons, MMedSc...................................................... Physiology

Dissertation: The effects of maslinic acid and related triterpene derivatives on kidney function of male Sprague-Dawley rats

Supervisors: Professor CT Musabayane and Professor FR Van Heerden


NDABAONLINE Article


The authors hypothesized that maslinic acid (MA) prevents development of kidney complications in diabetes due to its antioxidant properties. Therefore, they investigated the effects of MA treatment of streptozotocin (STZ)-induced diabetic rats on anti-oxidative status of cardiac, hepatic and renal tissues as well as on kidney function. Proximal tubular effects of MA were studied in anesthetized rats using lithium clearance. The results suggest antioxidant effects of MA ameliorate oxidative stress and improve kidney function in diabetes. 




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Mlisana, Koleka P

Mlisana, Koleka P, MBChB, MMed........................................................................... Medical Microbiology

Dissertation: The impact of sexually transmitted infections (STI) and genital tract inflammation on HIV-1 acquisition and rate of disease progression in subtype C infected women

Supervisors: Dr ABM Kharsany and Miss JS Passmore


NDABAONLINE Article


The candidate’s research on the role of immunological and viral factors following acquisition of HIV-1 subtype C infection in women, led to the development of a clinical algorithm to aid clinicians in diagnosing acute HIV infection in resource limited settings.  The high burden of asymptomatic sexually transmitted infections and genital inflammation in these women during early HIV-1 infection was associated with higher viral load set-point and CD4 cell depletion leading to rapid HIV disease progression and impacts on the design of HIV prevention interventions to prevent onward transmission.

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Naidoo, Mergan

Naidoo, Mergan, MBChB, MFamMed............................................................................... Family Medicine

Dissertation: Improving obstetric surgical safety in Kwazulu-Natal

Supervisor: Professor J Moodley



Maternal health is a priority of the NDoH. Mergan Naidoo’s thesis is critical to improving care provided to pregnant women. Surgical safety is of particular concern due to rising caesarean section rates in South Africa and globally. This dissertation shows that the implementation of a modified WHO Surgical Safety Checklist prior to C/S will possibly decrease morbidity and mortality related to this procedure. 

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Naidoo, Sarita

Naidoo, Sarita, BSc, BScHons.................................................................................... Medical Microbiology

Dissertation: Antimicrobial susceptibility testing of Trichomonas vaginalis susceptibility testing of Trichomonas vaginalis

Supervisor: Professor AW Sturm


NDABAONLINE Article


Trichomoniasis is a protozoal infection of the genitalia, mainly affecting women. It impacts negatively on pregnancy outcome. Cases of treatment failure are difficult to manage.  The candidate performed susceptibility tests of the organism and found poor correlation between the laboratory test and treatment outcome. She explored possible reasons for this lack of correlation. The work guides further research that may ultimately provide the solution for this public health problem. 

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Naidoo, Thinagrin Dhasarathun

Naidoo, Thinagrin Dhasarathun, MBChB(Royal College of Surgeons)............ Obstetrics and Gynaecology

Dissertation: Post-Partum anal sphincter injury an altered faecal continence in a developing country: is there variation in incidence between Black Africans and Indians

Supervisor: Professor J Moodley


NDABAONLINE ARTICLE


Intrapartum care is receiving attention by health care workers and the community through the media. Dr Naidoo’s dissertation on postpartum faecal injuries is extremely relevant as it evaluates the frequencies of these complications in different racial groups and provides new information on the use of ultrasound to detect anal sphincter injuries. Such information is valuable to obstetricians, gynaecologists and urologists. 

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Ngubane, Phikelelani Siphosethu

Ngubane, Phikelelani Siphosethu, BMedScHons, MMedSc........................................................ Physiology

Dissertation: The effects of insulin and Syzygium aromaticum oleanolic acid containing dermal patches on kidney function and renal expression of glucose transporters in streptozotocin induced-diabetic rats

Supervisor: Professor CT Musabayane


The tight glycaemic control required to attenuate chronic complications in type 1 diabetes mellitus often requires numerous daily injections of bolus insulin is associated with increased Na+ retention resulting in hyperinsulinaemic oedema and hypertension The focus of this study was to determine whether sustained controlled insulin release from insulin-containing dermal patches can improve the impaired renal fluid and electrolyte handling of streptozotocin (STZ)-induced diabetic rats.

Transdermal insulin treatment also decreased the renal expressions of GLUT1 and SGLT1 of STZ-induced diabetic rats. We conclude that PI dermal patches deliver physiologically relevant amounts of insulin that can improve kidney function in diabetes.

 

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Paruk, Farhanah

Paruk, Farhanah, MBChB.............................................................................................................. Medicine

Dissertation: Hip fracture and osteoporosis: A comparison of the demographic profile, risk factors, outcomes and health care costs in geriatric patients with and without osteoporotic hip fractures in the public health sector in the eThekwini area

Supervisor: Professor B Cassim


NDABAONLINE Article


This study is the first to document the incidence, risk factors and outcome of hip fractures in South Africa. The study showed an increasing incidence of hip fractures in all ethnic groups and both genders, a high mortality with over one third of subjects dying within year and a high morbidity in survivors.  As the population ages, these results are relevant to our communities and will inform future health policy and management of this devastating condition.

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Radebe, Mopo Annah

Radebe, Mopo Annah, NDip(WitsTech), BTech(UJ), MTech(UJ).................................................. Virology

Dissertation: Patterns and features of HIV-1-specific CD8+ T-cell responses during acute HIV-1 infection and their association with viral control

Supervisor: Professor PT Ndung'U


NDABAONLINE Article


Cytotoxic T cells play an important role in HIV immune control.  This study identified the earliest cytotoxic T cell responses generated following HIV infection.  The study found that responses directed at the HIV Gag protein are associated with viral control but show delayed appearance kinetics and do not always persist.  Furthermore, most immune responses generated during acute HIV infection did not cause harmful mutations in HIV.   This study provides a rational basis for the design of HIV vaccines.

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Ramsugit, Saiyur

Ramsugit, Saiyur, BSc, BMedScHons........................................................................ Medical Microbiology

Dissertation: The role of Mycobacterium tuberculosis pili as an adhesin

Supervisor: Dr M Pillay


NDABAONLINE Article


This study identified MTP as a novel M. tuberculosis virulence factor, which is involved in biofilm formation and adhesion to and invasion of host cells. The findings suggest that MTP may be a useful target for the development of anti-biofilm and anti-infection therapeutics against tuberculosis. Three papers were published and 2 papers are under review. Part of the work was featured in the ‘World Biomedical Frontiers’ journal.

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Rawatlal Kamilla Varsha

Rawatlal, Kamilla Varsha..........................................................................Counselling Psychology

Dissertation : The development, implementation and evaluation of interventions to build school connectedness-A pilot study

Supervisor : Prof Inge Petersen – (School of Applied Social Sciences-Psychology)


NDABAONLINE Article

 

Whole school interventions incorporating interventions at multiple levels can improve social and emotional functioning and academic performance in exposed children, as well as reduce risk behavior. Ms Rawatlal’s pilot study provides a contextually appropriate model for implementing a whole school approach in South African schools and was described by examiners as having implications for informing policy for the development of whole school approaches in South Africa

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Maharajh, Ashok

Maharajh, Ashok, BCom(Gen), BComHons, MSportSc....................................................... Sports Science

Dissertation: A comparative socio-economic impact analysis of the comrades marathon on the cities of Pietermarizburg and Durban

Supervisor: Professor HJ Van Heerden


NDABAONLINE Article


The Comrades Marathon is a mega sports event characterized by endurance, epitomizing physical and psychological perseverance.  A comparative socio-economic impact analysis of the 2010 Comrades Marathon on the Cities of Pietermaritzburg and Durban was conducted.  During the 2010 event a grand total of R130 978 314 was generated by participants, their families and friends, of which R110 340 612 was spent in Durban and R20 637 702 in Pietermaritzburg, respectively. Additional intangible benefits were generated locally and nationally and significant unquantifiable benefits for the local economy were realized through presentation of the cities positively to the South African television audience and to its potential participants and supporters. The study has utility for the planning of similar potential mega-events in KZN, such as the Commonwealth and Olympic Games. 

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Moonsamy, Suri

Moonsamy, Suri, BSc, BMedScHons, MMedSc................................................. Pharmaceutical Chemistry

Dissertation: Diverse computational tools towards the understanding of HIV targets and design of potential drug candidates

Supervisor: Professor MES Soliman


NDABAONLINE Article


HIV/AIDS still remains to be a challenging epidemic infecting millions of individuals worldwide. Despite on-going HIV/AIDS research and access to antiretroviral therapy, to date still no cure exists for this deliberating disease. This PhD study focused on the development of more effective therapeutic interventions for the treatment and cure of HIV/AIDS through computational approaches. In recent years, computational approaches have emerged as close counterparts to experiments in modern drug discovery process and in understanding complex biological phenomena. Several new protocols to select and study the drug resistance mechanism and dynamic behavior of drug able proteins were investigated. Through several reports, my studies provided potential clues for further design of novel drug candidates that are less susceptible to drug resistance.

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Muslim, Tufayl Ahmed

Muslim, Tufayl Ahmed, BDentThrpy(UKZN), PGDip(Ed)(UKZN), PGDip(Law)(UKZN), MScDent(UWC), MTechQual(DUT)................................................................................................................ Dental Therapy

Dissertation: A comparative analysis of oral healthcare policy development between a developed country (Australia) and a developing country (South Africa)

Supervisor: Dr S Singh


NDABAONLINE Article


The candidate developed a cross-national policy conceptual framework to guide oral health policy analysis in South Africa and Australia.

 

The results indicated a mismatch between policy development; human resource planning and access to oral health services, coupled with an absence of clearly defined analytical tools to evaluate oral health systems development. The conceptual framework developed for this study provides a broad-based systematic tool that could assist health policy analyses in other settings. 

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Ndabarora, Eleazar

Ndabarora, Eleazar, BNHons, MN, PhD........................................................................................ Nursing

Dissertation: Development of an intervention model for  data quality management and health information use at community and district levels in Rwanda

Supervisors: Professor LR Uys and Dr J Chipps


NDABAONLINE Article


The study sought to develop an intervention model for health data quality management and health information use at community and district levels in Rwanda.  Poor health data quality management and health information use at community and District levels in Rwanda was observed. Challenges identified were poor management of District Health Information Systems, lack of institutional support and a lack of an information culture.  A Model which included training, supervision, engagement of stakeholders, feedback initiatives, computerization and leadership and coordination was developed 

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Ofili, Mary Isioma

Ofili, Mary Isioma, BScHons(OAU), MSc(OAU)............................................................................. Nursing

Dissertation: An ethnographic study of predictors of hypertension and its preventive strategies in a rural community in Delta State Nigeria

Supervisor: Professor BP Ncama


NDABAONLINE Article


Hypertension prevalence in Ibusa rural community was found to be 44%; with increasing age, increasing body mass index and high salt intake being prominent risk factors for hypertension. Traditional and cultural practices associated with hypertension management in that community were identifiedthrough individual in-depth interviews. Guidelines for the prevention, management and referral of hypertension in rural underserved communities by non-professionals through the Nominal Group Technique method consisting of a group of experts were developed.

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Ojewole, Elizabeth Bolanle

Ojewole, Elizabeth Bolanle, BPharm(UNigeria), MPharm(UStrathclyde)........................... Pharmaceutics

Dissertation: Exploring the buccal delivery potential of an antiretroviral drug

Supervisor: Professor T Govender


NDABAONLINE Article


The buccal delivery potential of didanosine was investigated to overcome disadvantages associated with oral administration of ARV drugs. The study confirmed its buccal permeability and enhancement mechanisms and toxicity with Aloe vera gel (AVgel 0.5%w/v) and novel oleic acid derivatives (OA1ANa 2%w/w). The enhancers can be selected to design and optimize buccal delivery systems to improve therapy. Didanosine buccal films were also successfully formulated and evaluated. 

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Orton, Penelope Margaret

Orton, Penelope Margaret, BA(UNISA), BNHons, MN................................................................... Nursing

Dissertation: Access to higher education in the health sciences- A policy implementation analysis

Supervisors: Professor P Brysiewicz and Professor SY Essack


NDABAONLINE Article


This study identified factors affecting access to health sciences education at universities in South Africa using a mixed methods sequential exploratory design. Results indicated that achieving equity of access in medicine and other mainstream health professional programmes is multi-factorial and has diverse and complex challenges. Guidelines and Policy Briefs for the Implementation of the Access Policy in Health Sciences Education and Access for Success in Health Sciences Education in Universities were developed.

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Reddy, Preshani

Reddy, Preshani......................................................Physiotherapy

Dissertation: Evidence to inform the development of physiotherapy guidelines for HIV-infected and HIV non-infected women following obstetric and gynaecological surgery.

Supervisor: Professor J. M Frantz

Co-supervisor: Dr M. Moodley

University: University of the Western Cape

 

Improving the health of women is presently a global priority. Clinical guideline development is a way of improving the quality of health care in South Africa. However, there are presently no clinical guidelines for women post caesarean section delivery and hysterectomy, which are the most common procedures performed by obstetricians and gynaecologists. This study thus aimed to provide evidence to inform the development of physiotherapy guidelines for HIV-infected and HIV non-infected women following obstetric and gynaecological surgery. The thesis has substantial value in advancing the development of clinical guidelines in an area where there is a dearth of information. The conceptual framework used in the study can also be employed in other facets of health care to develop guidelines in areas with a similar dearth of information. 




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